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Source: (Adapted from Costa FF, Agre P, Watkins PC, et al: Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin, N Engl J Med 323:1046, 1990.) Band 3, protein 4.2, and RhAG, members of the ankyrin complex, link their associated proteins and the bilayer membrane to the cytoskeletal proteins through ankyrin

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Due to the decreased expression and activity of antioxidant enzymes, the antioxidant capacity of cells is insufficient to resist the large amounts of ROS produced by fluoride, which results in cell damage, imbalance of cell redox homeostasis, and finally apoptosis